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KMID : 0861120080120030067
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Korean Journal of Oriental Preventive Medicine
2008 Volume.12 No. 3 p.67 ~ p.80
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Effects of Demethoxycurcumin Isolated from Radix Curcumae on Arterial Restenosis in Rats
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Gil In-Ho
Chong Myong-Soo
Shin Chang-Ho
Pae Hyun-Ock
Chung Hun-Taeg
Lee Ki-Nam
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Abstract
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The pathobiologic process of arterial stenosis following balloon angioplasty continues to be an enigmatic problem in clinical settings. This study investigates the ability of demethoxycurcumin, a curcuminoid isolated from Radix Curcumae, to attenuate balloon injury-induced neointima(NI) formation in the rat carotid artery. It was found that demethoxycurcumin induced inducible heme oxygenase(HO-1) expression and inhibited dose-dependently cellular proliferation in rat vascular smooth muscle cells. Perivascular application of demethoxycurcumin immediately following injury significantly reduced NI area and NI thickness 2 weeks post-injury. Interestingly, treatment with tin-protoporphyrin IX, a HO inhibitor, reversed the effects of demethoxycurcumin on NI formation. These results implicate demethoxycurcumin as a potent new therapeutic agent that is capable of reducing post-angioplasty arterial stenosis through induction of the HO-1 expression.
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KEYWORD
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demethoxycurcumin, Radix Curcumae, Arterial Restenosis
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